VHL Gene and Protein
The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that in humans is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau disease.
Vhl knockout mouse models
For Vhl gene, both proximal (Vhl-Sglt2-Cre) and distal (Vhl-Ksp-Cre) tubule knockout mouse models do not develop kidney tumors.
